醛糖还原酶
Aldose Reductase, recombinant
Wako
Storage condition: Keep at -20 degrees C.
规格:0.4UNITS
Summary
This product is for research use only. Do not administer it to human.
Origin: Human muscle cell
Specific activity: 1.4 - 1.6 units/mg
Concentration: 1 units/mL
MW: approx. 36,000
Preparation: The enzyme is dissolved in 5 mM DTT, 50% glycerin and 50
mM Sodium phosphate buffer solution (pH 7.0).
Aldose Reductase is purified from the culture medium containing
baculovirus-insect cell line 32d gene expression system. cDNA
containing the entire protein coding region is expressed, and the
enzyme exhibits the same properties and characteristics of human
muscle and retina.
Aldose Reductase catalyzes the reduction of glucose to sorbitol.
Sorbitol is subsequently converted to fructose by sorbitol
dehydrogenase.
These two enzymes are key components of the polyol pathway, the
alternate route of glucose metaboli***. It is suggested that aldose
reductase is involved in the pathogenesis of diabetic complicati***
and the inhibitors continue to be developed at a vigorous pace.
[Reference]
Nishimura, C. et al.: Biochim Biophys. Acta., 1078,
171 (1991).
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