Okadaic Acid
Wako
Grade: for Biochemistry
Regulation / Hazardous: UN: Class 6.1 - Toxic
Storage condition: Keep at 2-10 degrees C.
Manufacturer: Wako
Summary
This product is for research use only. Do not administer it to human.
Marine Natural Products-- Phosphatase Inhibitor
Okadaic acid is a causative agent of diarrhetic shellfish poisoning isolated from the sponge Halichondria Okadai. Okadaic Acid exhibits various activities as follows:
Contractile effect on ***ooth muscles in Ca2+ free solution.
Non-TPA type promoting agent of carcinogenesis.
Acceleration of protein phosphorylation through the specific inhibition of phosphatase.
[Solubility]
Soluble in ether, acetone and ethyl acetate.
Very slightly soluble in chloroform and methanol.
Practically insoluble in water and n-hexane
[Source] Halichondria okadai
[Preparation] Tachibana and Uemura's method
[Toxicity] LD50 192 ug/kg (i.p. in mouse)
[Warnings and precauti***] This product is quite toxic.
Please handle this with auto/safety pipetter. In case of skin contact, rinse skin with plenty of water or shower.
[Related Products]
Okadaic Acid Ammonia Salt (#156-02211 (100 micro-g); #152-02213 (500 micro-g))
Okadaic Acid Sodium Salt (#159-02441 (100 micro-g))
Calyculin A (#032-14451 (100 micro-g); #038-14453 (10 micro-g))
Dinophysistoxin-1 (#042-28661 (100 micro-g))
Tautomycin (#209-12041 (100 micro-g))
UN No. 3462
Synonym Okadaic acid
Halochondrine A
1,7-Dioxaspiro[5.5]undecane, acanthifolicin deriv.
Spiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran], acanthifolicin deriv,
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
9,10-Deepithio-9,10-didehydroacanthifolicin
CAS NO. 78111-17-8
Molecular Formula ***4H68O13
Molecular Weight 805.00
Appearance: Lyophilisate
Purity: 80.0+% (HPLC)
Melting Point: 164 - 166 degrees C
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