New PEGylation reagents from chemicell
chemicell offers new polyethylene glycol (PEG) derivates which are synthesized under pharmaceutical conditi*** in water without any organic solvents and without toxic agents. All PEG derivates are delivered as sterile aqueous soluti***.
Application
The protection of biological macromolecules, peptides, antibodies, proteins, and oligonucleotides is of extreme importance in biological, immunological and pharmacological applicati***.
There is growing interest of PEG and its α- and/or ω-substituted derivates and the protection offered by the covalent attachment of PEG to target molecules. PEGylation has become the method of choice for the delivery of bio-pharmaceuticals.
Linear PEGs can offer one or two reactive groups that can bind with a functional group on the target molecule.
Advantages of PEGylation
Increased bio***ailability
Increased blood circulation of the target biomolecule / drug
Shielding receptor-mediated uptake by the reticuloendothelial system (RES)
Shielding of antigenic and immunogenic epitopes
Preventing recognition and degradation by proteolytic enzymes
Increasing the apparent size of polypeptides, thus reducing the renal filtration and altering biodistribution
Optimized pharmacokinetics
Decreased immunogenicity
Polyethylene glycol di-succinic acid
α,ω-Di-succinic acid poly-ethylene glycol PDS6-1
PDS6-5
PDS8-1
PDS8-5
PDS20-1
PDS20-5
Polyethylene glycol succinic acid
α-Methoxy-ω-succinic acid polyethylene glycol PMS5-1
PMS5-5
Polyethylene glycol di-phosphate
α,ω-Di-phosphate polyethylene glycol PDP6-1
PDP6-5
PDP8-1
PDP8-5
PDP20-1
PDP20-5
Polyethylene glycol phosphate
α-Methoxy-ω-phosphate poly-ethylene glycol PMP5-1
PMP5-5
Polyethylene glycol di-Cibacron Blue
α,ω-di-Cibacron Blue polyethylene glycol PDC6-1
PDC6-5
PDC8-1
PDC8-5
PDC20-1
PDC20-5
Polyethylene glycol Cibacron Blue
α-Methoxy-ω-Cibacron Blue polyethylene glycol PDC5-1
PDC5-5
Polyethylene glycol di-fluorescein
α,ω-Di-fluorescein poly-ethylene glycol PDF6-1
PDF6-5
PDF8-1
PDF8-5
PDF20-1
PDF20-5
Polyethylene glycol fluorescein
α-Methoxy-ω-fluorescein polyethylene glycol PMF5-1
PMF5-5
Polyethylene glycol di-amine
α,ω-Di-amine polyethylene glycol PDA6-1
PDA6-5
PDA8-1
PDA8-5
PDA20-1
PDA20-5
Polyethylene glycol amine
α-Methoxy-ω-amine polyethylene glycol PMA5-1
PMA5-5
Polyethylene glycol di-Rhodamine
α,ω-Di-Rhodamine polyethylene glycol PDR6-1
PDR6-5
PDR8-1
PDR8-5
PDR20-1
PDR20-5
Polyethylene glycol Rhodamine
α-Methoxy-ω-Rhodamine polyethylene glycol PMR5-1
PMR5-5
关于YARE:
YARE-PEG修饰性PEG产品特点及技术优势:
我们已经为我们的客户提供了十年的PEG修饰剂服务,我们一直致力于降***格,提高品质!
1、提供多种官能团修饰,性能好,纯度高,产品分子量可定制,产品聚合分散度(PDI)小于 1.05;
2、生产工艺简化,杂质低,品质稳定;
3、批量生产,成本可控;
4、可提供2000多种产品规格;
5、其他特殊规格可提供定制。
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聚乙二醇修饰化学和PEG修饰剂选择指南
移液器的日常清洗和维护***
样品瓶和隔垫的选择指南
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