AZA1，azaspiracid-1，CRM-AZA1，原多甲藻酸贝类***，腹泻性贝毒，DSP
贝类***的一种，属于原多甲藻酸（Azaspir acids）组。1996年2月被***分离出，生物起源尚无明确定论。为脂溶性聚醚化合物。毒性比较稳定，常规的烹饪和加工处理无法去除。检测方法为小鼠生物测定法和***液相色谱法。
AZA1是***常见的类型，在贝体内***组成中所占比例***高。AZA2和AZA3分别是AZA1的8-甲基和22-脱甲基衍生物，在***贝类中也比较常见，同时也存在于浮游植物样品中。AZA4和AZA5是AZA3的3-羟基和23-羟基衍生物，在贝类体内含量很少。AZA6是AZA1的空间异构体，AZA7-10 是AZA1 的羟基化衍生物，AZA11 是AZA2 的羟基化衍生物，这几种衍生物在贝类体内也有发现，但含量非常少。推测AZA4、AZA5、AZA7、AZA8、AZA9和AZA10可能是贝类体内生物转化的产物
Azaspiracid was first discovered in Ireland in 1995 after a human intoxication event linked to the c***umption of shellfish [1] and has since been observed in wide areas of West and Northwest Europe [2,3]. Azaspiracid-1 AZA1) is a marine biotoxin possessing unique spiro assemblies with both carboxyl and amine moieties [4,5]. The marine dinoflagellate Protoperidinium crassipes has been implicated in production of azaspiracids [6]. Recent toxicological studies indicate that AZA1 poses a significant threat to c***umers. Intoxication symptoms can include nausea, stomach cramps, headache, vomiting and diarrhea. Long-term studies indicate a possible carcinogenicity and tumor promoting abilities [7-8]. The maximum permissible level of AZA1 and some of analogues and metabolites in shellfish in the EU according to the directive EEC/225/2002 implementing the legislation EU/95/492 is currently 0.16 mg/kg in whole tissue.
CRM-AZA1 is designed for use as an instrument calibration solution to aid the analyst in the determination of AZA1 in plankton and shellfish samples. Each ampoule contains approximately 0.5 mL of solution with 1.47 &plu***n; 0.08 μmol/L AZA1 in methanol.
Azaspiracid (AZA1)Molecular Formula: ***7H71***2Formular Molecular Weight: 842.1Monoisotopic Mass: 841.4976CAS Registry No.: 214899-21-5