血小板内皮细胞黏附分子-1***

中文名称：

血小板内皮细胞黏附分子-1***

英文名称：

Anti-CD31(PECAM-1)

产品编号：

PL030195R

免 疫  原：

KLH conjugated synthetic peptide derived from human CD31 C-terminus

***类型：

Rabbit Polyclonal IgG

产品规格：

0.1mg/0.2mg

包装情况：

一支包装（原装进口、分装）

其他名称：

platelet endothelial cell adhesion molecule precursor-1; PECAM-1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; GPIIA; Pecam 1; PECAM 1 CD31 EndoCAM; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule.

背景介绍：

This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular juncti***. Type I membrane protein. SIZE: 738 amino acids; 82536 Da. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart. PTM: Phosphorylated on Ser and Tyr residues after cellular activation. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) 31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular juncti***. CD31 is implicated in several functi***, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Tyr-690 plays a critical role in leukocyte transendothelial migration (TEM) and is required for efficient trafficking of CD31 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. CD31 prevents phagocyte ingestion of closely apposed viable cells by tran***itting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies h***e also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

交叉反应
       物   种：

Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep, Bovine, （Please decide the specificity by homology）