兔抗人、大、小鼠、猪、犬***坏死因子-α***

中文名称：

兔抗人、大、小鼠、猪、犬***坏死因子-α***

英文名称：

Anti-TNF-alpha

产品编号：

PL030078R

免 疫  原：

KLH conjugated synthetic peptide derived from human TNF alpha

***类型：

Rabbit Polyclonal IgG

产品规格：

0.1mg/0.2mg

包装情况：

一支包装（原装进口、分装）

其他名称：

TNF-alpha; APC1; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNF-a; TNF alpha; TNF; TNF Macrophage Derived; TNF Monocyte Derived; TNF Superfamily Member 2; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor Precursor; Tumour Necrosis Factor Alpha; TNFSF1A.

背景介绍：

Growth Factor and Hormones Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide stimulated macrophages, and causes tumor necrosis when injected into tumour bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS PAGE under non reducing conditi***. TNF alpha is closely related to the 25 kDa protein Tumour Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular acti***. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with *** gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other acti*** of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

交叉反应
       物   种：

Human, Dog, Pig, Horse,

                 （Please decide the specificity by homology）