7-Keto-DHEA
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Product Name: 7-Keto-DHEA(7-Keto-dehydroepiandrosterone)
CAS: 566-19-8
Synonyms: DEHYDROEPIANDROSTERONE, 7-KETO; 5-androstene-3b-ol-7, 17-dione; 5-ANDROSTEN-3-BETA-OL-7, 17-DIONE
MF: C19H26O3
MW: 302.41
Assay: 99%
Properties: White fine crystalline powder
Usage: Pharmaceutical raw materials, the hormone
Description:
7-keto-DHEA is a by-product of dehydroepiandrosterone (DHEA), a chemical that is formed in the body. DHEA is a "parent hormone" produced by glands near the kidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood.
People take 7-keto-DHEA to speed up the metaboli*** and heat production to promote weight loss. 7-keto-DHEA is also used to improve lean body mass and build muscle, increase the activity of the thyroid gland, boost the immune system, enhance memory, and slow aging.
Applicati***:
7-oxodehydroepiandrosterone (7-oxo DHEA and more commonly known as the brand name 7-keto) is one of three oxygenated metabolites of Dehydroepiandrosterone, and these three oxygenated metabolites interconvert with one another but do not convert back into parent DHEA; 7-keto supplementation is a way to get these three oxygenated metabolites without using DHEA supplementation, and DHEA may form androgenic and estrogenic hormones via an alternate metabolic pathway (which 7-keto does not participate in).
7-keto supplementation is mostly known to not be hormonal; it can interact with steroid metaboli*** but the exact manner in which it does it not fully elucidated. It does appear to h***e anti-cortisol mechani***s as the enzymes that activate cortisol (from the relatively inactive precursors of cortisone and corticosterone) are the same that interconvert these oxygenated metabolites. Although it appears to be anti-cortisol by its mechani***s, there is insufficient evidence to support these mechani***s in the body following oral supplementation.
Studies using 7-keto supplementation tend to note an increased metabolic rate later on during a caloric restriction period (which is secondary to reducing the rate of metabolic rate decline associated with dieting, and becoming a relative increase) although the quantity of data on this is pretty minimal if we exclude studies with possible conflicts of interest or those that use 7-keto alongside a multitude of supplements.
7-keto appears to be a somewhat promising non-hormonal fat burning agent but requires more evidence on both of those claims.
How does it work:
7-keto-DHEA might promote weight loss by speeding up the body's metaboli***.
How to Take (recommended dosage, active amounts, other details):
A typical supplemental dosage of 7-keto is 200-400mg daily in two divided doses (100-200mg), some limited evidence suggests that lower doses of 50-100mg may be effective for neural purposes.
The optimal dosing schedule and overall dose of 7-keto is not yet known, and the above dosages are just based on what is known to h***e efficacy.