Ethinyl Estradiol
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CAS:57-63-6
Standard:USP34
Purity:99.85%
COA is ***ailable
Chemical name: 3- hydroxy -19- to a -17 alpha pregnane -1,3,5 (10) - three ene -20- alkyne 17 alcohol
Properties: white to cream white crystalline powder. Melting point of 145-146 ° C (semi-hydrate).
182-184 ° C (anhydrous). Soluble in ethanol, practically insoluble in water. Odorless.
The use of ethinyl estradiol: estrogen class.ethinyl estradiol for estrogen drugs. Effect of diethylstilbestrol, but ethinylestradiol 20 times as potent.
English Name: Ethinylestradiol
Molecular formula: C20H24O2
Molecular weight: 296.41
EINECS:200-342-2
Traits: ethinyl estradiol TC is white or off-white crystalline powder; odorless. Soluble in ethanol, isopropyl alcohol or ether, soluble in chloroform, insoluble in water.
Conclusion:The product complies with specification in USP34
Description:
1, supplement the lack of estrogen, the treatment of female sexual dysfunction, menopause, menopausal syndrome; (for advanced breast cancer in postmenopausal women), in the treatment of advanced prostate cancer; combined with progestogens drug, can inhibit ovulation, can be used as a contraceptive. Clinical mainly for inhibiting ovulation medicine; also used in children with cryptorchidi*** and hyperandrogeni***, pituitary tumor. For the diagnosis of hypothalamus - pituitary - gonadal dysfunction, according to the variation of sex hormone and sex hormone levels.
2, treatment of hypogonadotropic hypogonadi*** induced amenorrhea and infertility infertility, multiple ovarian follicles. With the weight loss related amenorrhea, should use the correct weight diet. Also used for prostate cancer (often used in combination with cyproterone or fluorine benzoyl imide), delayed puberty or early and endometrial different. Mainly used to inhibit ovulation, achieve the purpose of contraception.
Pharmacological effects: ethinyl estradiol in the hypothalamus and pituitary are positive, negative feedback effect, ***all dosage can stimulate gonadotropin secretion; high dose inhibits the secretion, thereby inhibiting ovarian oviposit, achieve the antifertility effect. This product can stimulate the synthesis and secretion of pituitary gonadotropin (FSH and LH), gonadotropin stimulated gonadotropin releasing hormone. The hypothalamus gonadotropin-releasing hormone regulated by many kinds of factors, including sex hormones in the circulation. Single agents use can increase sexual hormone in circulation; continuous use can cause adenohypophysis gonadotropin-releasing hormone receptor down-regulation, thereby reducing the secretion of sex hormones.