Rimonabant hydrochloride

Weight Loss Steroids White Pharmaceutical Intermediates Powder Rimonabant Hydrochloride For Fat Loss And Body Shaper
 
 
1.  Quick Detail:
 
product name Rimonabant hydrochloride 
Alias RIMONABANT HCL;Rimonabant(Acomplia) 
CAS 158681-13-1 
Molecular Formula H 
Molecular Weight 500.25 
Appearances white or off white solid 
Usage pharmaceutical intermediates 
 
 
2.  Description:
 
Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.
Under development by Sanofi-***entis, Acomplia (rimonabant) is a selective CB1 endocannabinoid receptor antagonist indicated for the treatment of obesity.
It works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.
 
3.  Applicati***:
 
Rimonabant has a f***orable safety profile and is generally well tolerated. Rimonabant is proving to be a very promising approach for managing two major and preventable risk factors for cardiovascular disease. This review summarizes the ***ailable evidence on the clinical efficacy and safety of rimonabant as a potential therapy for obesity and ***oking cessation.
Rimonabant hydrochloride also has potential as a treatment for ***oking cessation because the endocannabinoid system is involved in the body's resp***e to tobacco dependence.