Weight Loss Steroids White Anti Aging Pharmaceutical Drug Orlistat For Lean Muscle Gain 99% Min 96829-58-2
Orlistat
CAS Number: 96829-58-2
Molecular Formula: C29H53NO5
Molecular Weight: 495.73
Density: 0.976 g/cm3
Melting Point: <50º C
Boiling Point: 615.9 º C at 760 mmHg
Flash Point: 326.3 º C
Solubility: DMSO: 19 mg/mL in water
Appearance: White crystalline powder
Description:
Orlistat (also known as tetrahydrolipstatin) is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by Glaxo***ithKline in the United Kingdom and the United s primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.
Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces ever, due to its relative simplicity and stability, orlistat was chosen over lipstatin for development as an anti-obesity drug.
The effectiveness of orlistat in promoting weight loss is definite, though modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modificati***, such as diet and exercise, lose about 2-3 kilograms (4.4-6.6 lb) more than those not taking the drug over the course of a year.Orlistat also modestly reduces blood pressure, and appears to prevent the ***et of type 2 diabetes, whether due to weight loss itself or to other effects; in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40% in obese people.
Orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). These decrease with time, however, and are the most frequently reported adverse effects of the the United States and the European Union, orlistat is ***ailable for sale without a prescription. Over-the-counter approval was controversial in the United States, with c***umer advocacy group Public Citizen repeatedly opposing it on safety and efficacy grounds.Generic formulati*** of orlistat are ***ailable in some countries. In Australia it is listed as an S3 medication, which means it's ***ailable over the counter in pharmacies.
At times, such as in spring 2012, orlistat has come into short supply, with c***equent price increases because of non***ailability of one of the drug's components.
Medical uses
Orlistat is used for the treatment of obesity. The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body ter orlistat was stopped, a significant number of subjects regained weight-up to 35% of the weight they had lost.
The incidence of type 2 diabetes in an obese population over four years is decreased with orlistat (6.2%) compared to placebo (9.0%).Long-term use of orlistat also leads to a modest reduction in blood pressure (mean reducti*** of 2.5 and 1.9 mmHg in systolic and diastolic blood pressure respectively).
Product Name Orlistat
Synonyms (S)-2-FORMYLAMINO-4-METHYL-PENTANOIC ACID (S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYL ESTER; RO-18-0647; (-)-TETRAHYDROLIPSTATIN; N-FORMYL-L-LEUCINE (1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYL ESTER; XENICAL; (-)-Tetrahydrolipstatin(EquivalentToOrlistat); Orlipastat; (1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-D-leucinate; [(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl] (2S)-2-formamido-4-methyl-pentanoate
Molecular Formula C29H53NO5
Molecular Weight 495.7348
InChI InChI=1/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25?,26-,27-/m0/s1
CAS Registry Number 96829-58-2
Molecular Structure
Density 0.976g/cm3
Boiling point 615.9¡ãC at 760 mmHg
Refractive index 1.469
Flash point 326.3¡ãC
Vapour Pressure 4.23E-15mmHg at 25¡ãC
Assay 99%
Appearance White or white powder
3. COA:
TESTS Specificatione Results
Description White or almost crystalline powder White crystalline powder
Identification IR Conforms
Specific rotation -33 -35¡ã -34¡ã
Loss on drying <0.5% 0.35%
Melting point 42-45¡æ 42-44¡æ
Water <=2.0% 0.25%
Residual solvents n-hexane<=290ppm n-heptane<=5000ppm 20ppm 1260ppm
Assay(HPLC) >=96.0%(ON DRY BASIS) 97.4%