Prednisolone-21-acetate
1. Name: Prednisolone-21-acetate
2. CAS No. 52-21-1
3. Appearance: White crystal powder
4. Purity: 99%
5. Effect: Synthetic corticosteroid; Metabolically interconvertible with prednisone.
Product name Prednisolone-21-acetate
Appearance white crystalline powder Melting Point 240-244 °C
Molecular Formula C23H30O6 Molecular Weight 402.48
Cas No. 52-21-1 EINECS No. 200-134-1
Functi*** Synthetic corticosteroid; metabolically interconvertible with prednisone.
Applicati*** Pharmaceutical
Package Aluminum foil bag inside + carton box outside;1kg/bag+25kg/drum
Storage Store in a cool and dry place, keep away from direct strong and heat.
Shelf Life Two years if sealed and store away from direct sun light.
Product description:
Prednisolone is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditi***. It is the active metabolite of the drug prednisone[1] and is used especially in patients with hepatic failure, as these individuals are unable to metabolise prednisone into prednisolone.
Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditi*** such as asthma, uveitis, pyoderma gangrenosum, rheumatoid arthritis, ulcerative colitis, pericarditis, temporal arteritis and Crohn's disease, Bell's palsy, multiple sclerosis, cluster headaches, vasculitis, acute lymphoblastic leukemia and autoimmune hepatitis, systemic lupus erythematosus, Kawasaki disease and dermatomyositis. It is also used for treatment of sarcoidosis, though the mechani*** is unknown.
Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reacti*** affecting the eye.
Prednisolone can also be used as an immunosuppressive drug for organ transplants and in cases of adrenal insufficiency (Addison's disease).
Corticosteroids inhibit the inflammatory resp***e to a variety of inciting agents and, it is presumed, delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation.
Possible side-effects include fluid retention of the face (moon face, Cushing's syndrome), acne, c***tipation, and mood swings.
A lengthy course of prednisolone can cause bloody or black tarry stools from bleeding into the stomach (this requires urgent medical attention); filling or rounding out of the face; muscle cramps or pain; muscle weakness; nausea; pain in back, hips, ribs, arms, shoulders, or legs; reddish-purple stretch marks on arms, face, legs, trunk, or groin; thin and shiny skin; unusual bruising; urinating at night; rapid weight gain; and wounds that will not heal.
Prolonged use of prednisolone can lead to the development of osteoporosis which makes bones more fragile and susceptible to fractures. One way to help alleviate this side effect is through the use of calcium and vitamin D supplements.
COA:
Product name Prednisolone-21-acetate
Appearance White crystalline powder
Chromatographic purity Any individual impurity not more than 1.0% Total impurities not more than 2.0% 0.4% 1.2%
Loss on drying Not more than 0.5% 0.3%
Residue on ignition Not more than 0.2% 0.05%
Residual solvents Methanol¡Ü3000ppm Methylene Chloride¡Ü600ppm Chloroform¡Ü60ppm Tetrahydrofuran¡Ü720ppm 385ppm Not detect out Not detect out Not detect out
Assay Between 97.0% and 102.0% 98.8%
Micronixation 90% not more than 10 micr*** 90% not more than 10 aicr***