Prednisolone Base CAS No: 50-24-8
Standard: EP/USP/BP
Model NO.: 50-24-8
Appearance: White or almost White crystalline powder
Specific Optical: +167 -+175
Rotation: 169
Identification: Positive
Product description:
Prednisolone is a steroid. It prevents the release of substances in the body that cause ednisolone is used to treat many different conditi*** such as allergic disorders, skin conditi***, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders. Prednisolone may also be used for purposes not listed in this medication guide.
Prednisolone is a synthetic adrenal corticosteroid. Corticosteroids are natural substances produced by the adrenal glands located adjacent to the kidneys. Corticosteroids h***e potent anti-inflammatory properties, and are used in a wide variety of inflammatory conditi*** such as arthritis, colitis, asthma, bronchitis, certain skin rashes, and allergic or inflammatory conditi*** of the nose and eyes. There are numerous preparati*** of corticosteroids including tablets, capsules, liquids, topical creams and gels, inhalers, eye drops, as well as injectable and intr***enous soluti***. The FDA approved prednisolone in June 1955.
Prednisolone is used to achieve prompt suppression of inflammation in many inflammatory and allergic conditi***. Examples of inflammatory conditi*** include rheumatoid arthritis, systemic lupus, acute gouty arthritis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Severe allergic conditi*** that fail conventional treatment may also respond to prednisolone. Examples include bronchial asthma, allergic rhinitis, drug-induced dermatitis, and contact and atopic dermatitis. Chronic skin conditi*** treated with prednisolone include dermatitis herpetiformis, pemphigus, severe psoriasis and severe seborrheic dermatitis. Chronic allergic and inflammatory conditi*** of the uvea, iris, conjunctiva and optic nerves of the eyes are also treated with prednisolone.
Prednisolone also is used in the treatment of blood cell cancers (leukemiias), and lymph gland cancers (lymphomas). Blood diseases involving destruction of platelets by the body's own immune cells (idiopathic thrombocytopenia purpura), and destruction of red blood cells by immune cells (autoimmune hemolytic anemia) can also be treated with prednisolone. Other miscellaneous conditi*** treated with prednisolone include thyroiditis and sarcoidosis. Prednisolone is also used as a hormone replacement in patients whose adrenal glands are unable to produce sufficient amounts of corticosteroids.
COA of the Prednisolone
Product name Prednisolone
Appearance White crystalline powder
Chromatographic purity Any individual impurity not more than 1.0% Total impurities not more than 2.0% 0.5% 1.2%
Loss on drying Not more than 0.5% 0.25%
Residue on ignition Not more than 0.2% 0.06%
Residual solvents Methanol¡Ü3000ppm Methylene Chloride¡Ü600ppm Chloroform¡Ü60ppm Tetrahydrofuran¡Ü720ppm 400ppm Not detect out Not detect out Not detect out
Assay Between 97.0% and 102.0% 99.1%
Micronixation 90% not more than 10 micr*** 90% not more than 10 aicr***